منابع مشابه
Section 4: -Cell Mass and Function in Type 2 Diabetes IRS Proteins and -Cell Function
Insulin receptor substrate (IRS) proteins mediate a variety of the metabolic and growth-promoting actions of insulin and IGF-1. After phosphorylation by activated receptors, these intracellular signaling molecules recruit various downstream effector pathways including phosphatidylinositol 3-kinase and Grb2. Ablation of the IRS-2 gene produces a diabetic phenotype; mice lacking IRS-2 display per...
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CONTEXT Prolactin is one of the most potent growth stimulating growth hormones of pancreatic beta cells. OBJECTIVE We investigated the role of prolactin on the proliferation of the beta-cell line INS-1. DESIGN In particular, we investigated the involvement of intracellular signal transduction molecules in prolactin-dependent upregulation of INS-1 growth. SETTING The effect of prolactin on...
متن کاملEffect of 8-week Aerobic Exercise on Undercarboxylated Osteocalcin and Beta Cell Function in Postmenopausal Women
ABSTRACT Background and Objective: The present study aims at investigating the possible effect of 8-week aerobic exercise on undercarboxylated osteocalcin and beta cell function in postmenopausal women. Methods: The study included 20 postmenopausal women with mean weight, height and b...
متن کاملcompactifications and function spaces on weighted semigruops
chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...
15 صفحه اولIRS proteins and the common path to diabetes.
Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors to the intracellular signaling cascades provided an important step forward. Moreover, Insulin/IGF receptors use common signaling pathways to accomplish many tasks, the IRS proteins add a unique laye...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2001
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.50.2007.s140